MyBioSource.com's Anti-Hu CD42a Purified is a Mouse monoclonal antibody. The Anti-Hu CD42a Purified Antibody was generated using GP9 as the antigen. It reacts with Human, and Canine. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency